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Wiki Wiki Summary
Transcription factor In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The function of TFs is to regulate—turn on and off—genes in order to make sure that they are expressed in the desired cells at the right time and in the right amount throughout the life of the cell and the organism.
Composite material A composite material (also called a composition material or shortened to composite, which is the common name) is a material which is produced from two or more constituent materials. These constituent materials have notably dissimilar chemical or physical properties and are merged to create a material with properties unlike the individual elements.
Contact Telecom Contact Telecom is a telecommunications and IT services company that develops data processing and software services for the telecommunications industry, established in 1998.\nBased in Manchester, New Hampshire, Contact Telecom offers carriers, service providers, telecommunication companies, Internet service providers, wireless, voice over IP, competitive local exchange carriers, incumbent local exchange carriers, cable companies and cloud computing providers a way to manage their invoice and usage data through cost management, revenue assurance and customer care initiatives.
Sonic's Ultimate Genesis Collection Sonic's Ultimate Genesis Collection (Sega Mega Drive Ultimate Collection in PAL regions) is a compilation of video games developed by Backbone Entertainment and published by Sega for PlayStation 3 and Xbox 360. The compilation features 48 Sega games (49 counting two versions of Altered Beast) which were previously released for the Sega Genesis (including most of the Sonic the Hedgehog titles released for the system), arcades and the Master System.
The Challenge (TV series) The Challenge (originally known as Road Rules: All Stars, followed by Real World/Road Rules Challenge) is a reality competition show on MTV that is spun off from two of the network's reality shows, The Real World and Road Rules. Originally featuring alumni from these two shows, casting for The Challenge has slowly expanded to include contestants who debuted on The Challenge itself, alumni from other MTV franchises including Are You the One?, Ex on the Beach (Brazil, UK and US), Geordie Shore and from other non-MTV shows.
Dandelin spheres In geometry, the Dandelin spheres are one or two spheres that are tangent both to a plane and to a cone that intersects the plane. The intersection of the cone and the plane is a conic section, and the point at which either sphere touches the plane is a focus of the conic section, so the Dandelin spheres are also sometimes called focal spheres.The Dandelin spheres were discovered in 1822.
Collecting the Kid Collecting the Kid is a compilation album by El-P. It was released through Definitive Jux on October 19, 2004.The album is not intended as a direct follow-up to Fantastic Damage, but instead collects together various B-sides, instrumentals, film soundtracking work, and beats El-P has previously produced for other artists.
Bill Belichick William Stephen Belichick (; born April 16, 1952) is an American professional football coach who is the head coach of the New England Patriots of the National Football League (NFL). He exercises extensive authority over the Patriots' football operations, effectively making him the team's general manager as well.
Silk Road (marketplace) Silk Road was an online black market and the first modern darknet market. As part of the dark web, it was operated as a Tor hidden service, such that online users were able to browse it anonymously and securely without potential traffic monitoring.
Incremental dating Incremental dating techniques allow the construction of year-by-year annual chronologies, which can be temporally fixed (i.e., linked to the present day and thus calendar or sidereal time) or floating.\nArchaeologists use tree-ring dating (dendrochronology) to determine the age of old pieces of wood.
Japanese asset price bubble The Japanese asset price bubble (バブル景気, baburu keiki, "bubble economy") was an economic bubble in Japan from 1986 to 1991 in which real estate and stock market prices were greatly inflated. In early 1992, this price bubble burst and Japan's economy stagnated.
Decolonizing Methodologies Decolonizing Methodologies: Research and Indigenous Peoples is a book by Linda Tuhiwai Smith. Originally published in 1999, Decolonizing Methodologies is a seminal text in indigenous studies that explores the intersections of colonialism and research methodologies.
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Carrier frequency offset Carrier frequency offset (CFO) is one of many non-ideal conditions that may affect in baseband receiver design. In designing a baseband receiver, we should notice not only the degradation invoked by non-ideal channel and noise, we should also regard RF and analog parts as the main consideration.
List of most successful German U-boats List of successful U-boats contains lists of the most successful German U-boats in the two World Wars based on total tonnage.\n\n\n== World War I ==\nThis list contains the 5 most successful German U-boats during the First World War based on total tonnage.
Periodic counter-current chromatography Periodic counter-current chromatography (PCC) is a method for running affinity chromatography in a quasi-continuous manner. Today, the process is mainly employed for the purification of antibodies in the biopharmaceutical industry as well as in research and development.
Vision City (Rwanda) Vision City is multi-phase housing development in Kigali, Rwanda currently being built by Ultimate Developers LTD for the Rwanda Social Security Board. At 4500 units and a total cost of 150 million USD it is the largest residential housing project in the country's history.
Instructional design Instructional design (ID), also known as instructional systems design (ISD), is the practice of systematically designing, developing and delivering instructional materials and experiences, both digital and physical, in a consistent and reliable fashion toward an efficient, effective, appealing, engaging and inspiring acquisition of knowledge. The process consists broadly of determining the state and needs of the learner, defining the end goal of instruction, and creating some "intervention" to assist in the transition.
Boeing X-51 Waverider The Boeing X-51 Waverider is an unmanned research scramjet experimental aircraft for hypersonic flight at Mach 5 (3,300 mph; 5,300 km/h) and an altitude of 70,000 feet (21,000 m). The aircraft was designated X-51 in 2005.
Body modification Body modification (or body alteration) is the deliberate altering of the human anatomy or human physical appearance. In its broadest definition it includes skin tattooing, socially acceptable decoration (e.g., common ear piercing in many societies), and religious rites of passage (e.g., circumcision in a number of cultures), as well as the modern primitive movement.
Mining engineering Mining in the engineering discipline is the extraction of minerals from underneath, open pit, above or on the ground. Mining engineering is associated with many other disciplines, such as mineral processing, exploration, excavation, geology, and metallurgy, geotechnical engineering and surveying.
Patriot Act The USA PATRIOT Act (commonly known as the Patriot Act) was a landmark Act of the United States Congress, signed into law by President George W. Bush. The formal name of the statute is the Uniting and Strengthening America by Providing Appropriate Tools Required to Intercept and Obstruct Terrorism (USA PATRIOT) Act of 2001, and the commonly used short name is a contrived acronym that is embedded in the name set forth in the statute.The Patriot Act was enacted following the September 11 attacks and the 2001 anthrax attacks with the stated goal of dramatically tightening U.S. national security, particularly as it related to foreign terrorism.
Financial crisis of 2007–2008 The financial crisis of 2008, or Global Financial Crisis, was a severe worldwide economic crisis that occurred in the early 21st century. It was the most serious financial crisis since the Great Depression (1929).
Financialization Financialization (or financialisation in British English) is a term sometimes used to describe the development of financial capitalism during the period from 1980 to present, in which debt-to-equity ratios increased and financial services accounted for an increasing share of national income relative to other sectors.\nFinancialization describes an economic process by which exchange is facilitated through the intermediation of financial instruments.
Recruitment Recruitment refers to the overall process of identifying, sourcing, screening, shortlisting, and interviewing candidates for jobs (either permanent or temporary) within an organization. Recruitment can also refer to the processes involved in choosing individuals for unpaid roles.
ISO 10218 ISO 10218 Robots and robotic devices — Safety requirements for industrial robots is an international standard for industrial robot safety, developed by ISO/TC 184/SC 2 "Robots and robotic devices" in parallel with the European Committee for Standardization. It consists of two parts:\n\nPart 1: Robots\nPart 2: Robot systems and integrationAs a European standard it has the designation EN ISO 10218-1 and -2 (not to be mixed with EN 10218).ISO/TS 15066 was published in 2016 to address the new field of safety requirements for cobots.Revisions to the original standard have been planned by the ISO/TC 299 committee.
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Queen's Regulations The Queen's Regulations (first published in 1731 and known as the King's Regulations when the monarch is a king) is a collection of orders and regulations in force in the Royal Navy, British Army, Royal Air Force, and Commonwealth Realm Forces (where the same person as on the British throne is also their separate head of state), forming guidance for officers of these armed services in all matters of discipline and personal conduct. Originally, a single set of regulations were published in one volume.
Federal government of the United States The federal government of the United States (U.S. federal government or U.S. government) is the national government of the United States, a federal republic in North America, composed of 50 states, a city within a federal district (the city of Washington in the District of Columbia, where the entire federal government is based), five major self-governing territories and several island possessions. The federal government is composed of three distinct branches: legislative, executive, and judicial, whose powers are vested by the U.S. Constitution in the Congress, the president and the federal courts, respectively.
Public relations Public relations (PR) is the practice of managing and disseminating information from an individual or an organization (such as a business, government agency, or a nonprofit organization) to the public in order to affect their public perception. Public relations (PR) and publicity differ in that PR is controlled internally, whereas publicity is not controlled and contributed by external parties.
Many-worlds interpretation The many-worlds interpretation (MWI) is an interpretation of quantum mechanics that asserts that the universal wavefunction is objectively real, and that there is no wave function collapse. This implies that all possible outcomes of quantum measurements are physically realized in some "world" or universe.
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Competitor Group Competitor Group, Inc. (CGI) is a privately held, for-profit, sports marketing and management company based in Mira Mesa, San Diego, California.
Risk Factors
APRIA HEALTHCARE GROUP INC ITEM 1A RISK FACTORS Apria has identified the following important factors that could cause actual results to differ materially from those projected in any forward-looking statements the company may make from time to time
Collectibility of Accounts Receivable—Apria’s failure to maintain its controls and processes over billing and collecting or the deterioration of the financial condition of its payors could have a significant negative impact on its results of operations and financial condition
The collection of accounts receivable is one of Apria’s most significant challenges and requires constant focus and involvement by management and ongoing enhancements to information systems and billing center operating procedures
Further, some of Apria’s payors and/or patients may experience financial difficulties, or may otherwise not pay accounts receivable when due, resulting in increased write-offs
There can be no assurance that Apria will be able to maintain its controls and processes over billing or its current levels of collectibility and days sales outstanding in future periods
If Apria is unable to properly bill and collect its accounts receivable, its results will be adversely affected
Medicare/Medicaid Reimbursement Rates—Continued reductions in Medicare and Medicaid reimbursement rates could have a material adverse effect on Apria’s results of operations and financial condition
There are a number of provisions contained within recent legislation and proposed legislation that affect or may affect reimbursement policies for items and services provided by Apria
Certain of such provisions reduced 2004 net revenues by approximately dlra15 million and 2005 net revenues by an incremental dlra27 million
Other reimbursement changes in the legislation are still outstanding and will further reduce Apria’s net revenues
In 2001, some states began adopting alternative pricing methodologies for certain drugs and biologicals under the Medicaid program
In a number of states, these changes have reduced the level of reimbursement received by Apria without a corresponding offset or increase to compensate for the service costs incurred
In several of those states, Apria elected to stop accepting new Medicaid patient referrals for the affected drugs and biologicals
Further, some states are considering other reductions in Medicaid reimbursement as they work through their respective state’s budget process
Medicare and Medicaid payments accounted for approximately 32prca and 7prca of Apria’s 2005 net revenues, respectively
Apria cannot be certain of the ultimate impact of all legislated and contemplated changes or provide assurance to its investors that additional reimbursement reductions will not be made
Operating Systems and Controls—Apria’s failure to successfully implement computer and other system modifications designed to maximize productivity could ultimately have a significant negative impact on its results of operations and financial condition
Apria’s management has identified a number of areas throughout its operations where it intends to modify the current processes or systems in order to attain a higher level of productivity
The ultimate cost savings expected from the successful design and implementation of such initiatives will be necessary to help offset the impact of Medicare reimbursement reductions and continued downward pressure on pricing
Apria’s failure to successfully implement its planned system modifications and other productivity improvements could have a significant impact on its operations and financial condition
Further, the implementation of these system changes could have a disruptive effect on related transaction processing and operations
Government Regulation; Healthcare Reform—Non-compliance with laws and regulations applicable to Apria’s business and future changes in those laws and regulations could have a material adverse effect on Apria
Apria is subject to stringent laws and regulations at both the federal and state levels, requiring compliance with burdensome and complex billing, substantiation and record-keeping requirements
Financial relationships between Apria and physicians and other referral sources are also subject to strict limitations
In addition, strict licensing and safety requirements apply to the provision of services, pharmaceuticals and equipment
Violations of these laws and regulations could subject Apria to severe fines, facility shutdowns and possible exclusion from participation in federal healthcare programs such as Medicare and Medicaid
Government officials and the public will continue to debate healthcare reform
Changes in healthcare law, new interpretations of existing laws, or changes in payment methodology may have a dramatic effect on Apria’s business and results of operations
Pricing Pressures—Apria believes that continued pressure to reduce healthcare costs could have a material adverse effect on the company
The current market continues to exert pressure on healthcare companies to reduce healthcare costs, resulting in reduced margins for home healthcare providers such as Apria
Larger group purchasing organizations and supplier groups exert additional pricing pressure on home healthcare providers
These include managed care organizations, which control an increasing portion of the healthcare economy
Apria has a number of contractual arrangements with managed care organizations and other parties, although no individual arrangement accounted for more than 9prca of Apria’s net revenues in 2005
The segment of the healthcare market in which Apria operates is highly competitive
In each of its service lines, there are a number of national providers and numerous regional and local providers
Other types of healthcare providers, including industrial gas manufacturers, individual hospitals and hospital systems, home health agencies and health maintenance organizations have entered, and may continue to enter the market to compete with Apria’s various service lines
Some of these competitors have access to significantly greater financial and marketing resources than Apria